[Carbamazepine-induced hyponatremia].

Interferon-alpha is a predisposing risk factor for carbamazepine-induced hyponatremia: A case of syndrome of inappropriate antidiuresis caused by interferon-alpha therapy

A 31-year-old man had been treated with carbamazepine (CBZ) for 6 years and warfarin with bucolome for 2 years before developing hyponatremia 7 days after an injection of interferon-alpha 2b and starting oral ribavirin for chronic hepatitis C virus infection. Despite the hyponatremia, urinary osmolality exceeded plasma osmolality, and urinary excretion volume decreased markedly after water load...

Pre-operative Carbamazepine-induced Hyponatraemia: Should We Accept a Reset Hypo-osmolar Baseline and Proceed with Surgery?

Transient Splenial Lesion Following Abrupt Withdrawal of Carbamazepine

Transient splenial lesion (TSL) of the corpus callosum is associated with various disorders, including encephalitis, seizure and metabolic disturbances (1). We herein report a patient showing TSL after switching antiepileptic medications. A 46-year-old woman with epilepsy had been taking carbamazepine for decades. Asymptomatic hyponatremia (125 mEq/L) was detected, and carbamazepine was switche...

Severe hyponatremia in a patient treated with levomepromazine and carbamazepine.

A 40-year-old man was brought to hospital because of grand mal seizures in July, 2000. Seven hours before admission, he vomited once and drank approximately 6 liters of water within two hours because of throat discomfort. Thirty minutes later, he suffered six grand mal seizures. His medical history included cerebral palsy at the age of one year complicated with mental retardation and absence ep...

Evidence for a direct adverse reaction of neuroleptics in self-induced water intoxication of psychiatric patients.

A mentally retarded patient who developed polydipsia and hyponatremia following the long-term use of neuroleptics is described. Before the investigation, he was treated with a combination of five drugs: diazepam, propericiazine, carbamazepine, lithium carbonate and trihexyphenidyl. The treatment was switched to diazepam alone; to propericiazine, trihexyphenidyl and diazepam; to carbamazepine an...